The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 22, 2023
Filed:
May. 02, 2017
Applicant:
Massachusetts Institute of Technology, Cambridge, MA (US);
Inventors:
Paiman Peter Ghoroghchian, Boston, MA (US);
Haihua Xiao, Cambridge, MA (US);
Ruogu Qi, Houston, TX (US);
Ting Li, Xi'an, CN;
Assignee:
Massachusetts Institute of Technology, Cambridge, MA (US);
Primary Examiner:
Int. Cl.
CPC ...
A61K 9/00 (2006.01); A61K 48/00 (2006.01); A61K 47/60 (2017.01); A61K 47/64 (2017.01); C12N 15/113 (2010.01); A61K 33/243 (2019.01); A61K 47/69 (2017.01); A61K 31/555 (2006.01); C08G 81/00 (2006.01); C12N 15/11 (2006.01); A61K 9/107 (2006.01); A61K 31/282 (2006.01); A61K 47/34 (2017.01); C07K 2/00 (2006.01); C08G 69/10 (2006.01); C12N 15/90 (2006.01); A61K 47/10 (2017.01); A61K 39/00 (2006.01); C12N 15/09 (2006.01); G01N 21/47 (2006.01);
U.S. Cl.
CPC ...
A61K 48/0041 (2013.01); A61K 9/107 (2013.01); A61K 31/282 (2013.01); A61K 31/555 (2013.01); A61K 33/243 (2019.01); A61K 47/10 (2013.01); A61K 47/34 (2013.01); A61K 47/60 (2017.08); A61K 47/646 (2017.08); A61K 47/6907 (2017.08); A61K 47/6935 (2017.08); A61K 48/005 (2013.01); C07K 2/00 (2013.01); C08G 69/10 (2013.01); C08G 81/00 (2013.01); C12N 15/11 (2013.01); C12N 15/113 (2013.01); C12N 15/90 (2013.01); A61K 2039/585 (2013.01); C12N 15/09 (2013.01); C12N 2310/20 (2017.05); G01N 21/47 (2013.01);
Abstract
Disclosed are copolymer micelles for simultaneous delivery of Cas9 mRNA and guide RNA for Cas9 CRISPR gene editing. Also disclosed are copolymer micelles for simultaneous delivery of a therapeutic or diagnostic nucleic acid and a cross-linking or alkylating anticancer agent.