The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 22, 2023
Filed:
Jan. 15, 2016
Applicant:
City of Hope, Duarte, CA (US);
Inventors:
Andreas Herrmann, Pasadena, CA (US);
Hua Yu, Glendora, CA (US);
Assignee:
City of Hope, Duarte, CA (US);
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 38/14 (2006.01); C07K 16/18 (2006.01); A61K 47/54 (2017.01); C07K 16/00 (2006.01); A61P 35/00 (2006.01); A61K 39/08 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
A61K 38/14 (2013.01); A61K 39/08 (2013.01); A61K 47/549 (2017.08); A61P 35/00 (2018.01); C07K 16/00 (2013.01); C07K 16/18 (2013.01); A61K 38/00 (2013.01); C07K 2317/74 (2013.01); C07K 2317/77 (2013.01);
Abstract
Provided herein are cell penetrating conjugates. The conjugates include a non-cell penetrating protein attached to a phosphorothioate nucleic acid or phosphorothioate polymer backbone through a non-covalent linker including a biotin-binding domain and a biotin domain, wherein the phosphorothioate nucleic acid or phosphorothioate polymer backbone enhances intracellular delivery of the non-cell penetrating protein. Also provided are compositions and kits comprising the conjugates.