The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 22, 2023
Filed:
Jun. 28, 2022
Applicant:
A2 Biotherapeutics, Inc., Agoura Hills, CA (US);
Inventors:
Yuta Ando, Agoura Hills, CA (US);
Julyun Oh, Agoura Hills, CA (US);
Han Xu, Agoura Hills, CA (US);
Carl Alexander Kamb, Agoura Hills, CA (US);
Assignee:
A2 Biotherapeutics, Inc., Agoura Hills, CA (US);
Primary Examiner:
Int. Cl.
CPC ...
A61K 35/17 (2015.01); C07K 14/725 (2006.01); C07K 16/28 (2006.01); C07K 16/30 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
A61K 35/17 (2013.01); C07K 14/7051 (2013.01); C07K 16/2809 (2013.01); C07K 16/2833 (2013.01); C07K 16/2863 (2013.01); C07K 16/30 (2013.01); A61K 2039/507 (2013.01); C07K 2317/622 (2013.01); C07K 2319/03 (2013.01);
Abstract
The disclosure relates to immune cells comprising a dual receptor system responsive to loss of heterozygosity in a target cell, and methods of making and using same. The first receptor comprises activator receptor specific to a HER2 antigen, and the second receptor comprises an inhibitory receptor specific to an antigen lost in cancer but not wild type cells, that inhibits activation of the immune cells by the first receptor.