The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 15, 2023
Filed:
Feb. 13, 2020
Applicant:
Regents of the University of Minnesota, Minneapolis, MN (US);
Inventors:
Jonathan N. Sachs, Minneapolis, MN (US);
Chih Hung Lo, Minneapolis, MN (US);
Assignee:
REGENTS OF THE UNIVERSITY OF MINNESOTA, Minneapolis, MN (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 33/50 (2006.01); G01N 33/68 (2006.01); G01N 21/64 (2006.01);
U.S. Cl.
CPC ...
G01N 33/502 (2013.01); G01N 21/6486 (2013.01); G01N 33/6896 (2013.01);
Abstract
The present disclosure provides methods for identifying compounds that cause structural changes in tau protein monomer and oligomer conformation. The methods include the use of cells that include tau proteins labeled with one or more chromophores, and exposing the cells to a test compound. The method further includes detecting a change in fluorescence resonance energy transfer (FRET) between the chromophores.