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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11726078 B1

PDFFull Text
Date of Patent:
Aug. 15, 2023

Filed:

Nov. 06, 2020

Device for rapid detection of tuberculosis-lipoarabinomannan (tb-lam) with enhanced sensitivity

Applicants:

General Electric Company, Schenectady, NY (US);

Tokitae Llc, Bellevue, WA (US);

Inventors:

Matthew Jeremiah Misner, Delanson, NY (US);

Gregory Andrew Grossmann, Halfmoon, NY (US);

Cathryn Ellen Olsen, Wilton, NY (US);

John Richard Nelson, Clifton, NY (US);

David Roger Moore, Rexford, NY (US);

Paul Michael Smigelski, Jr., Glenville, NY (US);

John Thomas Connelly, Seattle, WA (US);

Benjamin David Grant, Bellevue, WA (US);

Bernhard Hans Weigl, Seattle, WA (US);

Assignees:

General Electric Company, Schenectady, NY (US);

Tokitae LLC, Bellevue, WA (US);

Attorney:

Fletcher Yoder P.C.

Primary Examiner:

Christopher Adam Hixson

Int. Cl.
CPC ...
G01N 33/493 (2006.01); C07K 1/22 (2006.01); B01D 15/08 (2006.01); G01N 33/50 (2006.01); G01N 33/569 (2006.01); B01D 63/02 (2006.01); A61B 10/00 (2006.01); C12M 1/26 (2006.01); G01N 33/558 (2006.01); G01N 15/14 (2006.01);
U.S. Cl.
CPC ...
G01N 33/493 (2013.01); A61B 10/007 (2013.01); B01D 15/08 (2013.01); B01D 63/02 (2013.01); C07K 1/22 (2013.01); C12M 33/14 (2013.01); G01N 33/5038 (2013.01); G01N 33/558 (2013.01); G01N 33/569 (2013.01); G01N 33/5695 (2013.01); A61M 2202/005 (2013.01); A61M 2202/0028 (2013.01); A61M 2202/0071 (2013.01); A61M 2202/0496 (2013.01); G01N 2015/1493 (2013.01);
Abstract

A device for rapid detection of a tuberculosis lipoarabinomannan (TB-LAM) is provided. The device includes a pre-concentrator unit for concentrating the TB-LAM comprising: an ion-exchange medium comprising one or more ligands configured to capture the TB-LAM from the source biological sample, wherein the captured-TB-LAM is eluted from the ion-exchange medium as an eluate comprising a concentrated form of TB-LAM; a cassette; a lateral flow assay unit disposed in the cassette; and an integration unit attached to the pre-concentrator unit and the cassette. The integration unit is configured to operatively couple and de-couple the pre-concentrator unit and the cassette. The pre-concentrator unit and the lateral flow assay unit disposed in the cassette are in a fluidic communication in a coupled form. The device for rapid detection of TB-LAM further comprises a dilutor unit.

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