The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 15, 2023
Filed:
Dec. 14, 2018
Applicant:
Ionis Pharmaceuticals, Inc., Carlsbad, CA (US);
Inventors:
Michael Oestergaard, Carlsbad, CA (US);
Punit P. Seth, Carlsbad, CA (US);
Frank Rigo, Carlsbad, CA (US);
Chrissa A. Dwyer, San Diego, CA (US);
Assignee:
Ionis Pharmaceuticals, Inc., Carlsbad, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/113 (2010.01); A61K 9/00 (2006.01);
U.S. Cl.
CPC ...
C12N 15/1137 (2013.01); A61K 9/0085 (2013.01); C12N 15/113 (2013.01); C12N 2310/11 (2013.01); C12N 2310/113 (2013.01); C12N 2310/31 (2013.01); C12N 2310/315 (2013.01); C12N 2310/321 (2013.01); C12N 2310/322 (2013.01); C12N 2310/3231 (2013.01); C12N 2310/3341 (2013.01); C12N 2310/351 (2013.01); C12N 2310/3515 (2013.01); C12N 2310/3535 (2013.01); C12N 2320/32 (2013.01);
Abstract
The present disclosure provides half duplex compounds comprising a first oligomeric compound and a second, shorter, oligomeric compound, wherein the first oligomeric compound is complementary to a target nucleic acid and the second oligomeric compound is complementary to the first oligomeric compound. In certain embodiments, the compounds disclosed herein are useful for modulating the expression of extra-hepatic target nucleic acids.