The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 15, 2023
Filed:
May. 17, 2021
Applicant:
Yale University, New Haven, CT (US);
Inventors:
David Spiegel, New Haven, CT (US);
Ryan Murelli, Belleville, NJ (US);
Andrew Zhang, Waltham, MA (US);
Assignee:
YALE UNIVERSITY, New Haven, CT (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 47/54 (2017.01); A61K 47/68 (2017.01); A61K 45/06 (2006.01); C07K 16/44 (2006.01); C07K 16/30 (2006.01); A61K 31/4192 (2006.01); C07D 249/04 (2006.01); A61K 9/00 (2006.01); A61K 47/64 (2017.01); A61K 47/55 (2017.01);
U.S. Cl.
CPC ...
C07K 16/44 (2013.01); A61K 9/0019 (2013.01); A61K 31/4192 (2013.01); A61K 45/06 (2013.01); A61K 47/54 (2017.08); A61K 47/549 (2017.08); A61K 47/55 (2017.08); A61K 47/646 (2017.08); A61K 47/68 (2017.08); A61K 47/6803 (2017.08); A61K 47/6869 (2017.08); A61K 47/6873 (2017.08); A61K 47/6891 (2017.08); C07D 249/04 (2013.01); C07K 16/3069 (2013.01); C07K 2317/31 (2013.01);
Abstract
The present invention relates to chimeric chemical compounds which are used to recruit antibodies to cancer cells, in particular, prostate cancer cells or metastasized prostate cancer cells. The compounds according to the present invention comprise an antibody binding terminus (ABT) moiety covalently bonded to a cell binding terminus (CBT) through a linker and optionally, a connector molecule.