The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 15, 2023
Filed:
Nov. 20, 2020
The Broad Institute, Inc., Cambridge, MA (US);
Dana-farber Cancer Institute, Inc., Boston, MA (US);
The General Hospital Corporation, Boston, MA (US);
Nathanael S. Gray, Boston, MA (US);
Yanke Liang, Belmont, MA (US);
Hwan Geun Choi, Chestnut Hill, MA (US);
Thomas Sundberg, Boston, MA (US);
Alykhan Shamji, Somerville, MA (US);
Ramnik Xavier, Brookline, MA (US);
David E. Fisher, Newton, MA (US);
Nisma Mujahid, Spencerport, NY (US);
THE GENERAL HOSPITAL CORPORATION, Boston, MA (US);
DANA-FARBER CANCER INSTITUTE, INC., Boston, MA (US);
THE BROAD INSTITUTE, INC., Cambridge, MA (US);
Abstract
The present disclosure provides compounds of Formula (I), (II), and (III). The provided compounds are able to bind protein kinases (e.g., SIK) and may be useful in modulating (e.g., inhibiting) the activity of a protein kinase (e.g., SIK, (e.g., SIK1, SIK2, or SIK3)) in a subject or cell. The provided compounds may be useful in treating or preventing a disease (e.g., proliferative disease, musculoskeletal disease, genetic disease, hematological disease, neurological disease, painful condition, psychiatric disorder, or metabolic disorder) in a subject in need thereof. Also provided are pharmaceutical compositions, kits, methods, and uses that include or involve a compound described herein.