The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 15, 2023

Filed:

Dec. 12, 2018
Applicant:

Chiesi Farmaceutici S.p.a., Parma, IT;

Inventors:

Alessandro Accetta, Parma, IT;

Fabio Rancati, Parma, IT;

Christine Edwards, Parma, IT;

Gurdip Bhalay, Parma, IT;

Patrizia Tisselli, Parma, IT;

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 471/04 (2006.01); A61K 9/00 (2006.01); A61K 31/407 (2006.01); A61K 31/496 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
C07D 471/04 (2013.01); A61K 9/008 (2013.01); A61K 9/0075 (2013.01); A61K 9/0078 (2013.01); A61K 31/407 (2013.01); A61K 31/496 (2013.01); A61K 45/06 (2013.01);
Abstract

The invention relates to compounds of formula (I) inhibiting Rho Kinase that are meta tyrosine derivatives, processes for preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. Particularly the compounds of the invention may be useful in the treatment of many disorders associated with ROCK enzymes mechanisms, such as pulmonary diseases including asthma, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH).


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