The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 15, 2023
Filed:
Jan. 18, 2018
Applicants:
Albert Einstein College of Medicine, Bronx, NY (US);
Drexel University, Philadelphia, PA (US);
Palacky University Olomouc, Olomouc, CZ;
Inventors:
Sridhar Mani, Riverdale, NY (US);
Felix Kopp, Brooklyn, NY (US);
Zdenek Dvorak, Olomouc, CZ;
Sandhya Kortagere, Newtown, PA (US);
Chamini Karunaratne, Mamaroneck, NY (US);
Assignees:
Albert Einstein College of Medicine, Bronx, NY (US);
Drexel University, Philadelphia, PA (US);
Palacky University Olomouc, Olomouc, CZ;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61P 1/00 (2006.01); C07D 401/06 (2006.01); C07D 209/12 (2006.01); C07D 471/04 (2006.01);
U.S. Cl.
CPC ...
C07D 401/06 (2013.01); A61P 1/00 (2018.01); C07D 209/12 (2013.01); C07D 471/04 (2013.01);
Abstract
Small molecule agonists of the pregnane X receptor (PXR), compositions and methods are disclosed for treating or preventing gut barrier dysfunction, an illness associated with gut barrier dysfunction, toxic or inflammatory injury to intestines, or leaky intestinal (gut) syndrome in a subject.