The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 15, 2023
Filed:
Apr. 14, 2017
Applicant:
Research Institute AT Nationwide Children's Hospital, Columbus, OH (US);
Inventors:
Louise Rodino-Klapac, E. Groveport, OH (US);
Jerry R. Mendell, Columbus, OH (US);
Assignee:
RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL, Columbus, OH (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/86 (2006.01); C12N 15/864 (2006.01); C07K 14/47 (2006.01); A61K 48/00 (2006.01); A61K 38/17 (2006.01); A61K 31/7088 (2006.01); C12N 15/11 (2006.01); C12N 15/113 (2010.01); A61P 21/00 (2006.01); A61K 9/00 (2006.01); A61P 19/04 (2006.01); A61K 35/761 (2015.01);
U.S. Cl.
CPC ...
A61K 48/005 (2013.01); A61K 9/0019 (2013.01); A61K 31/7088 (2013.01); A61K 35/761 (2013.01); A61K 38/1709 (2013.01); A61K 38/1719 (2013.01); A61K 48/0058 (2013.01); A61K 48/0075 (2013.01); A61P 19/04 (2018.01); A61P 21/00 (2018.01); C07K 14/4708 (2013.01); C12N 15/111 (2013.01); C12N 15/113 (2013.01); C12N 15/86 (2013.01); C12N 15/8645 (2013.01); C12N 2310/141 (2013.01); C12N 2320/31 (2013.01); C12N 2330/51 (2013.01); C12N 2750/14141 (2013.01); C12N 2750/14143 (2013.01); C12N 2800/22 (2013.01); C12N 2830/008 (2013.01);
Abstract
The invention provides for recombinant AAV vectors comprising a miniaturized human micro-dystrophin gene and methods of using the recombinant vectors to reduce or prevent fibrosis in subjects suffering from muscular dystrophy.