The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 15, 2023

Filed:

Sep. 17, 2019
Applicants:

Dana-farber Cancer Institute, Inc., Boston, MA (US);

The Brigham and Women's Hospital, Inc., Boston, MA (US);

Consejo Nacional DE Investigaciones Cientificas Y Técnicas (Conicet), Ciudad de Buenos Aires, AR;

Fundacion Sales, Ciudad Autonoma de Buenos Aires, AR;

Inventors:

Margaret Shipp, Wellesley, MA (US);

Jing Ouyang, Chestnut Hill, MA (US);

Kunihiko Takeyama, Tokyo, JP;

Jeffery L. Kutok, Natick, MA (US);

Scott J. Rodig, Westwood, MA (US);

Gabriel Rabinovich, Ciudad de Buenos Aires, AR;

Diego Omar Croci Russo, Provincia de Buenos Aires, AR;

Mariana Salatino, Buenos Aires, AR;

Assignees:

Dana-Farber Cancer Institute, Inc., Boston, MA (US);

The Brigham and Women's Hospital, Inc., Boston, MA (US);

Consejo Nacional De Investigaciones Científicas y Técnicas (CONICET), Ciudad de Buenos Aires, AR;

Fundacion Sales, Ciudad Autonoma de Buenos Aires, AR;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 33/574 (2006.01); G01N 33/563 (2006.01); C07K 16/30 (2006.01); A61K 39/395 (2006.01); C07K 16/18 (2006.01); C07K 16/22 (2006.01); A61K 45/06 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
A61K 39/3955 (2013.01); A61K 45/06 (2013.01); C07K 16/18 (2013.01); C07K 16/22 (2013.01); A61K 2039/505 (2013.01); C07K 2317/34 (2013.01); C07K 2317/73 (2013.01); C07K 2317/76 (2013.01);
Abstract

The present invention is based, in part, on the discovery that galectin-1 (Gal1) plays a role in viral-associated PTLD, e.g., EBV-associated PTLD and hypoxia associated angiogenesis disorders. Accordingly, the invention relates to compositions, kits, and method for diagnosing, prognosing, monitoring, treating and modulating viral-associated PTLD, e.g., EBV-associated PTLD and hypoxia associated angiogenesis disorders.


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