The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 15, 2023

Filed:

Oct. 09, 2017
Applicants:

Beth Israel Deaconess Medical Center, Inc., Boston, MA (US);

Trustees of Boston University, Boston, MA (US);

Inventors:

Ara Nazarian, Wellesley, MA (US);

Edward Rodriguez, Medfield, MA (US);

Mark Grinstaff, Boston, MA (US);

Assignees:
Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 38/22 (2006.01); C07K 14/575 (2006.01); C07K 1/107 (2006.01); A61K 47/69 (2017.01); A61K 47/60 (2017.01); A61P 19/02 (2006.01); A61K 9/00 (2006.01); A61K 9/16 (2006.01); A61K 47/42 (2017.01); A61M 3/00 (2006.01);
U.S. Cl.
CPC ...
A61K 38/2221 (2013.01); A61K 9/0019 (2013.01); A61K 9/16 (2013.01); A61K 47/42 (2013.01); A61K 47/60 (2017.08); A61K 47/6903 (2017.08); A61M 3/005 (2013.01); A61P 19/02 (2018.01); A61M 2202/07 (2013.01); C07K 1/107 (2013.01); C07K 14/575 (2013.01);
Abstract

The present invention provides methods for treating a stiffened joint in a subject that comprise administering relaxin, e.g., a PEGylated relaxin-2, to the subject. The relaxin may be administered intra-articularly as a sustained release formulation. The present invention also provides sustained release formulations in the form of a hydrogel for administering polypeptides that are covalently attached to a polymer, e.g., PEG.


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