The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 15, 2023

Filed:

Aug. 31, 2017
Applicants:

Institut National DE LA Sante ET DE LA Recherche Medicale (Inserm), Paris, FR;

Centre National DE LA Recherche Scientifique (Cnrs), Paris, FR;

Université DE Paris, Paris, FR;

Assistance Publique—hopitaux DE Paris, Paris, FR;

Ecole Nationale Superieure DE Chimie DE Paris, Paris, FR;

Universite DE Versailles—st Quentin En Yvelines, Versailles, FR;

Inventors:

Robert Malafosse, Paris, FR;

Nathalie Mignet, Clamart, FR;

Vincent Boudy, Paris, FR;

Johanne Seguin, Kremlin Bicetre, FR;

Kathia Lemdani, Paris, FR;

Claude Capron, Boulogne, FR;

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/19 (2006.01); A61K 39/07 (2006.01); A61K 41/00 (2020.01); A61K 47/10 (2017.01); A61K 47/36 (2006.01); A61P 35/00 (2006.01); A61K 47/34 (2017.01); A61K 9/00 (2006.01); A61K 39/04 (2006.01); A61K 9/06 (2006.01); C07K 16/28 (2006.01); A61K 31/765 (2006.01); A61K 39/395 (2006.01); A61K 38/38 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
A61K 38/193 (2013.01); A61K 9/0019 (2013.01); A61K 9/0024 (2013.01); A61K 9/06 (2013.01); A61K 31/765 (2013.01); A61K 38/385 (2013.01); A61K 39/04 (2013.01); A61K 39/07 (2013.01); A61K 39/39541 (2013.01); A61K 41/0028 (2013.01); A61K 41/0052 (2013.01); A61K 47/10 (2013.01); A61K 47/34 (2013.01); A61K 47/36 (2013.01); A61P 35/00 (2018.01); C07K 16/2818 (2013.01); A61K 2039/505 (2013.01); A61K 2039/522 (2013.01); A61K 2039/54 (2013.01); A61K 2039/55522 (2013.01); A61K 2039/585 (2013.01); A61K 2039/82 (2018.08); C07K 2317/76 (2013.01);
Abstract

The present invention concerns a thermosensitive polymeric hydrogel comprising at least one thermosensitive copolymer, one aqueous solution, and a mucoadhesive excipient, wherein said thermosensitive polymeric hydrogel further comprises at least one immunostimulatory adjuvant and/or at least one cytokine and/or at least one chemokine and/or atleast one heat shockprotein. Another object of the invention is a thermosensitive polymeric hydrogel according to the invention for use in the treatment of tumors or metastasis in a subject having a cancer, preferably a metastatic cancer.


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