The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 15, 2023
Filed:
Oct. 16, 2020
Applicants:
Trustees of Boston University, Boston, MA (US);
The General Hospital Corporation, Boston, MA (US);
Inventors:
Mohammadreza Pakyari, Brookline, MA (US);
Wilson Wong, Brookline, MA (US);
Atsushi Okuma, Kagawa, JP;
Curtis Cetrulo, Cohasset, MA (US);
Assignees:
TRUSTEES OF BOSTON UNIVERSITY, Boston, MA (US);
THE GENERAL HOSPITAL CORPORATION, Boston, MA (US);
Primary Examiner:
Int. Cl.
CPC ...
A61K 35/17 (2015.01); A61K 38/17 (2006.01); A61K 39/44 (2006.01); C12N 5/0783 (2010.01); C07K 14/725 (2006.01); C07K 14/47 (2006.01); A61K 38/16 (2006.01); C12N 15/10 (2006.01);
U.S. Cl.
CPC ...
A61K 38/16 (2013.01); C07K 14/7051 (2013.01); C12N 15/102 (2013.01); C07K 2319/02 (2013.01); C07K 2319/73 (2013.01); C07K 2319/81 (2013.01);
Abstract
The technology described herein is directed to compositions comprising components of multi-component CALs or CARs, e.g., a TCR recognition domain; and one or both of: (a) an intracellular signaling domain; and (b) a first-type protein interaction domain. Further provided herein are methods for treating or preventing an autoimmune disease, a transplant rejection, or graft versus host disease.