The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 15, 2023

Filed:

May. 04, 2021
Applicant:

Heartbeet Ltd., Ashbocking Ipswich, GB;

Inventors:

Jon Lundberg, Djursholm, SE;

Eddie Weitzberg, Stockholm, SE;

Assignee:

Heartbeet Ltd., Ashbocking, GB;

Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 33/00 (2006.01); A61K 9/00 (2006.01); A61K 9/08 (2006.01); A61K 31/05 (2006.01); A61K 31/198 (2006.01); A61K 31/375 (2006.01); A61K 33/14 (2006.01); A61K 33/30 (2006.01); A61K 36/185 (2006.01); A61K 45/06 (2006.01); A23L 2/02 (2006.01); A23L 2/52 (2006.01); A23L 33/105 (2016.01); A23L 33/135 (2016.01); A23L 33/16 (2016.01); A61K 36/21 (2006.01); A61P 9/12 (2006.01); C01D 9/00 (2006.01);
U.S. Cl.
CPC ...
A61K 33/00 (2013.01); A23L 2/02 (2013.01); A23L 2/52 (2013.01); A23L 33/105 (2016.08); A23L 33/135 (2016.08); A23L 33/16 (2016.08); A61K 9/0056 (2013.01); A61K 9/0095 (2013.01); A61K 9/08 (2013.01); A61K 31/05 (2013.01); A61K 31/198 (2013.01); A61K 31/375 (2013.01); A61K 33/14 (2013.01); A61K 33/30 (2013.01); A61K 36/185 (2013.01); A61K 36/21 (2013.01); A61K 45/06 (2013.01); A61P 9/12 (2018.01); A23V 2002/00 (2013.01); C01D 9/00 (2013.01);
Abstract

Inorganic anions nitrate and nitrite influence metabolic rate and glucose homeostasis. Infusion of nitrite iv caused an acute drop in resting energy expenditure (oxygen consumption) and nitrate, when given perorally, caused a reduction in oxygen consumption during exercise and a depression of the increase in blood glucose observed after an oral glucose tolerance test. The doses of nitrate and nitrite did not cause any detectable change in methemoglobin levels of blood. Also, nitrate and nitrite did not alter lactate levels in blood. This discovery provides useful treatments to regulate the energy expenditure and glucose homeostasis of a mammal by administration of inorganic nitrite and/or nitrate.


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