The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 15, 2023
Filed:
Mar. 28, 2018
Applicant:
The University of North Carolina AT Chapel Hill, Chapel Hill, NC (US);
Inventors:
Mark H. Schoenfisch, Chapel Hill, NC (US);
Lei Yang, Carrboro, NC (US);
Assignee:
The University of North Carolina at Chapel Hill, Chapel Hill, NC (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/726 (2006.01); A01N 43/16 (2006.01); A01N 59/00 (2006.01); C08B 37/00 (2006.01); C12N 15/76 (2006.01); A61K 47/59 (2017.01); A61K 31/7036 (2006.01); C07H 15/234 (2006.01);
U.S. Cl.
CPC ...
A61K 31/726 (2013.01); A01N 43/16 (2013.01); A01N 59/00 (2013.01); A61K 31/7036 (2013.01); A61K 47/595 (2017.08); C08B 37/0063 (2013.01); C12N 15/76 (2013.01); C07H 15/234 (2013.01);
Abstract
Provided herein are hyperbranched polyaminoglycosides, where in some embodiments, the hyperbranched polyaminoglycosides are covalently modified to store and release nitric oxide. Some embodiments pertain to methods of making and use of hyperbranched polyaminoglycosides. In some embodiments, the covalently modified hyperbranched polyaminoglycosides may be tailored to release nitric oxide in a controlled manner and are useful for eradication of both gram positive and gram negative bacteria as well as other microbes.