The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 15, 2023
Filed:
Apr. 12, 2019
Umc Utrecht Holding B.v., Utrecht, NL;
Hugo Johannes Gerhardus Snippert, Utrecht, NL;
Alexander Eduard Edgar Mertens, Hilversum, NL;
Carla Sofia Leiria Verissimo, Utrecht, NL;
Johannes Lukas Bos, Bunnik, NL;
UMC Utrecht Holding B.V., Utrecht, NL;
Abstract
The invention relates to the combined use and to a combination of either a microtubule targeting agent or a Src kinase inhibitor, a Raf-MEK-ERK pathway inhibitor and an EGFR and/or ERBB2 inhibitor for use in the treatment of RAS-mutant cancer. The invention further relates to a method of treating RAS-mutant cancers and to a method of testing a combination comprising of a either microtubule targeting agent or a Src inhibitor, a Raf-MEK-ERK pathway inhibitor and an EGFR and/or ERBB2 inhibitor on a tumor organoid. In particular, the invention relates to the combined use of either a microtubule targeting agent or a Src kinase inhibitor with: an inhibitor of the Raf-MEK-ERK pathway and at least one of an inhibitor of both EGFR and ERBB2 and a combination of an EGFR inhibitor and an ERBB2 inhibitor in the treatment of RAS mutant cancer.