The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 08, 2023

Filed:

Dec. 14, 2020
Applicant:

The Usa As Represented BY the Secretary, Department of Health and Human Services, Bethesda, MD (US);

Inventors:

Deb K. Chatterjee, Potomac, MD (US);

Stanislaw J. Kaczmarczyk, Frederick, MD (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/86 (2006.01); A61K 39/00 (2006.01); A61K 39/12 (2006.01); A61K 45/06 (2006.01); C12N 7/00 (2006.01);
U.S. Cl.
CPC ...
C12N 15/86 (2013.01); A61K 39/0011 (2013.01); A61K 39/001117 (2018.08); A61K 39/001124 (2018.08); A61K 39/001129 (2018.08); A61K 39/001144 (2018.08); A61K 39/001152 (2018.08); A61K 39/001163 (2018.08); A61K 39/001181 (2018.08); A61K 39/001182 (2018.08); A61K 39/001191 (2018.08); A61K 39/001194 (2018.08); A61K 39/12 (2013.01); A61K 45/06 (2013.01); C12N 7/00 (2013.01); A61K 2039/5258 (2013.01); A61K 2039/53 (2013.01); A61K 2039/585 (2013.01); C12N 2740/11023 (2013.01); C12N 2740/11042 (2013.01); C12N 2770/36123 (2013.01); C12N 2770/36134 (2013.01); C12N 2770/36143 (2013.01); C12N 2770/36145 (2013.01); C12N 2770/36152 (2013.01); C12N 2770/36171 (2013.01); C12N 2800/24 (2013.01); C12N 2810/6081 (2013.01);
Abstract

Described herein is a method of preventing or treating a disease in a mammalian subject, comprising administering to the subject who is in need thereof an effective dosage of a pharmaceutical composition comprising a virus like particle (VLP) comprising: an alphavirus replicon comprising a recombinant polynucleotide, wherein the polynucleotide comprises a sequence encoding both subunits of a human class II major histocompatibility antigen, a retroviral gag protein, and a fusogenic envelope protein, wherein the VLP does not contain an alphavirus structural protein gene.


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