The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 08, 2023
Filed:
Mar. 13, 2018
Applicant:
Massachusetts Institute of Technology, Cambridge, MA (US);
Inventors:
Timothy Kuan-Ta Lu, Cambridge, MA (US);
Lior Nissim, Cambridge, MA (US);
Ming-Ru Wu, Brookline, MA (US);
Assignee:
Massachusetts Institute of Technology, Cambridge, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A01N 63/00 (2020.01); A61K 39/245 (2006.01); C07H 21/04 (2006.01); C12N 15/85 (2006.01); A61K 35/763 (2015.01); C12N 15/86 (2006.01);
U.S. Cl.
CPC ...
C12N 15/85 (2013.01); A61K 35/763 (2013.01); C12N 15/86 (2013.01); C12N 2710/16632 (2013.01); C12N 2710/16643 (2013.01); C12N 2830/008 (2013.01);
Abstract
Synthetic promoters that are differentially modulated between certain diseased cells (e.g., cancer cells) and normal cells (e.g., non-cancer cells) are described. The synthetic promoters may be used to drive expression of gene(s) of interest in a specific cell type or during a specific cellular state. These synthetic promoters are useful, for example, for targeted expression of therapeutic molecules in diseased cells.