The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 08, 2023
Filed:
Sep. 08, 2017
Applicant:
Bioatla, Inc., San Diego, CA (US);
Inventors:
Jay M. Short, Jackson, CA (US);
Hwai Wen Chang, San Marcos, CA (US);
Gerhard Frey, San Diego, CA (US);
Assignee:
BIOATLA, INC., San Diego, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/10 (2006.01); C07K 14/315 (2006.01); C12N 9/68 (2006.01); C12N 9/72 (2006.01); G01N 33/68 (2006.01); C07K 7/06 (2006.01); C07K 14/47 (2006.01); C07K 14/575 (2006.01); C12N 9/16 (2006.01); G01N 33/543 (2006.01); G01N 33/573 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C12N 15/102 (2013.01); C07K 7/06 (2013.01); C07K 14/3153 (2013.01); C07K 14/47 (2013.01); C07K 14/575 (2013.01); C07K 14/57545 (2013.01); C07K 14/57563 (2013.01); C12N 9/16 (2013.01); C12N 9/6435 (2013.01); C12N 9/6459 (2013.01); C12N 9/6462 (2013.01); C12N 15/1058 (2013.01); C12Y 304/21007 (2013.01); C12Y 304/21069 (2013.01); C12Y 304/21073 (2013.01); G01N 33/54306 (2013.01); G01N 33/573 (2013.01); G01N 33/6845 (2013.01); G01N 33/6854 (2013.01); A61K 38/00 (2013.01); C12Y 302/01035 (2013.01); C12Y 304/23015 (2013.01); C12Y 304/24029 (2013.01); Y02A 50/30 (2018.01);
Abstract
This disclosure relates to a method of generating conditionally active biologic proteins from wild type proteins, in particular therapeutic proteins, which are reversibly or irreversibly inactivated at the wild type normal physiological conditions. For example, evolved proteins are virtually inactive at body temperature, but are active at lower temperatures.