The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 08, 2023
Filed:
May. 07, 2021
Achillion Pharmaceuticals, Inc., Boston, MA (US);
Jason Allan Wiles, Madison, CT (US);
Avinash S. Phadke, Branford, CT (US);
Dawei Chen, Guilford, CT (US);
Venkat Rao Gadhachanda, Hamden, CT (US);
Joel Charles Barrish, Richboro, CT (US);
Atul Agarwal, Hamden, CT (US);
Kyle J. Eastman, New Haven, CT (US);
Achillion Pharmaceuticals, Inc., Boston, MA (US);
Abstract
Macrocyclic Complement Factor D inhibitors, pharmaceutical compositions, and uses thereof, as well as processes for their manufacture are provided. The compounds provided include Formula I, Formula II, Formula III, Formula IV, Formula V, Formula VI, Formula VII, and Formula VIII or a pharmaceutically acceptable salt, prodrug, isotopic analog, N-oxide, or isolated isomer thereof, optionally in a pharmaceutically acceptable composition. The inhibitors described herein target Factor D and inhibit or regulate the complement cascade.