The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 08, 2023

Filed:

Mar. 03, 2017
Applicants:

Memorial Sloan-kettering Cancer Center, New York, NY (US);

University of Washington, Seattle, WA (US);

Inventors:

Michel Sadelain, New York, NY (US);

Isabelle Riviere, New York, NY (US);

Jorge Mansilla-Soto, New York, NY (US);

Xiuyan Wang, New York, NY (US);

George Stamatoyannopoulos, Seattle, WA (US);

John Stamatoyannopoulos, Seattle, WA (US);

Mingdong Liu, Seattle, WA (US);

Assignees:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/86 (2006.01); C12N 15/63 (2006.01); A61K 48/00 (2006.01); C12N 15/11 (2006.01); C07K 14/805 (2006.01); C12N 9/22 (2006.01); C12N 15/85 (2006.01);
U.S. Cl.
CPC ...
A61K 48/0066 (2013.01); A61K 48/0058 (2013.01); C07K 14/805 (2013.01); C12N 9/22 (2013.01); C12N 15/85 (2013.01); C12N 15/86 (2013.01); C12N 2740/10043 (2013.01); C12N 2740/15043 (2013.01); C12N 2740/16043 (2013.01); C12N 2830/008 (2013.01); C12N 2830/15 (2013.01); C12N 2830/30 (2013.01); C12N 2830/40 (2013.01); C12N 2830/46 (2013.01); C12N 2830/48 (2013.01); C12N 2830/50 (2013.01);
Abstract

The presently disclosed subject matter provides for expression cassettes that allow for expression of a globin gene or a functional portion thereof, vectors comprising thereof, and cells transduced with such expression cassettes and vectors. The presently disclosed subject matter further provides methods for treating a hemoglobinopathy in a subject comprising administering an effective amount of such transduced cells to the subject.


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