The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 08, 2023
Filed:
Nov. 02, 2018
Applicant:
Del Mar Pharmaceuticals (Bc) Limited, Vancouver, CA;
Inventors:
Assignee:
Del Mar Pharmaceuticals (BC) Limited, Vancouver, CA;
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/336 (2006.01); A61P 35/00 (2006.01); A61K 31/047 (2006.01); A61K 31/519 (2006.01);
U.S. Cl.
CPC ...
A61K 31/336 (2013.01); A61K 31/047 (2013.01); A61K 31/519 (2013.01); A61P 35/00 (2018.01);
Abstract
Methods for treating diffuse intrinsic pontine glioma (DIPG) comprising administration of a therapeutically effective amount of an alkylating hexitol (such as dianhydrogalacitol, diacetyldianhydrogalacitol, and dibromodulcitol) are disclosed. Such methods may further comprise administration of other anti-cancer agents. In preferred embodiments, the secondary anti-cancer agent is an inhibitor of Wee1 tyrosine kinase (such as adavosertib). Methods of treating malignancies in general comprising administration of a combination of an alkylating hexitol and an inhibitor of Wee1 tyrosine kinase are also disclosed.