The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 01, 2023
Filed:
Oct. 05, 2018
Centre National DE LA Recherche Scientifique (Cnrs), Paris, FR;
Institut National DE LA Sante ET DE LA Recherche Medicale (Inserm), Paris, FR;
Sorbonne Universite, Paris, FR;
Marie-Charlotte Horny, Paris, FR;
Jean-Michel Siaugue, Choisy-le-Roi, FR;
Vincent Dupuis, Paris, FR;
Mathieu Lazerges, Paris, FR;
Jean Gamby, Saclay, FR;
Centre National de la Recherche Scientifique (CNRS), Paris, FR;
Institut National de La Sante et de la Recherche Medicale (INSERM), Paris, FR;
Sorbonne Universite, Paris, FR;
Abstract
A process for pre-concentration and detection of at least one single-stranded nucleic acid target molecule, the process comprising the steps of generating a flow of liquid comprising at least one magnetic nanoparticle in a micro-channel and a plurality of single-stranded nucleic acid probe molecules attached to the nanoparticle, generating an alternating magnetic field in the part of the micro-channel using an electromagnet, the magnetic field having an intensity and frequency that are suitable for causing magnetic hyperthermia of the nanoparticles so as to cause denaturing of the duplex formed by the single-stranded nucleic acid target molecule and the single-stranded nucleic acid probe molecule, and detecting the single-stranded target molecule dispersed in the liquid.