The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 01, 2023
Filed:
Jul. 19, 2019
Applicant:
Janssen Vaccines & Prevention B.v., Leiden, NL;
Inventor:
Taco Gilles Uil, Leiden, NL;
Assignee:
Janssen Vaccines & Prevention B.V., Leiden, NL;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/86 (2006.01); A61P 31/14 (2006.01); A61K 39/12 (2006.01); C07K 14/005 (2006.01);
U.S. Cl.
CPC ...
C12N 15/86 (2013.01); A61K 39/12 (2013.01); A61P 31/14 (2018.01); C07K 14/005 (2013.01); C12N 2750/14143 (2013.01); C12N 2750/14152 (2013.01); C12N 2770/24122 (2013.01); C12N 2830/006 (2013.01);
Abstract
Provided herein are adenoviral vectors comprising nucleotide sequences encoding a Zika virus M and Env antigen, wherein the nucleotide sequence encoding the Zika virus M and Env antigen is operably linked to a cytomegalovirus (CMV) promoter comprising at least one tetracycline operator (TetO) motif. Also provided herein are pharmaceutical compositions comprising the adenoviral vectors, methods of producing the adenoviral vectors, methods of preventing Zika virus or the progression of Zika virus in a subject in need thereof, and kits comprising the adenoviral vectors and host cells.