The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 01, 2023
Filed:
Jan. 17, 2019
Applicant:
The Florey Institute of Neuroscience and Mental Health, Parkville, AU;
Inventors:
Steven Petrou, Eltham, AU;
Eric G. Marcusson, San Francisco, CA (US);
Assignee:
The Florey Institute of Neuroscience and Mental Health, Parkville, AU;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/113 (2010.01); A61P 25/00 (2006.01); C12Q 1/68 (2018.01);
U.S. Cl.
CPC ...
C12N 15/1138 (2013.01); A61P 25/00 (2018.01); C12N 2310/11 (2013.01); C12N 2310/314 (2013.01); C12N 2310/315 (2013.01); C12N 2310/321 (2013.01); C12N 2320/34 (2013.01);
Abstract
Described herein are compositions and methods that are used to increase the expression of SCN2A, which may be used to treat neurological or psychiatric disorders. Antisense oligonucleotides that target upstream open reading frames (uORFs) may be administered to prevent translation initiation from a uORF to increase expression from a primary ORF (pORF), thus increasing the levels of SCN2A protein.