The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 01, 2023
Filed:
Mar. 08, 2019
Guangdong Zhaotai Invivo Biomedicine Co.,ltd, Guangdong, CN;
Peng Li, Guangdong, CN;
Ruocong Zhao, Guangdong, CN;
Zhaoyang Tang, Guangdong, CN;
Le Qin, Guangdong, CN;
Yuanbin Cui, Guangdong, CN;
Simiao Lin, Guangdong, CN;
Yao Yao, Guangdong, CN;
GUANGDONG ZHAOTAI INVIVO BIOMEDICINE CO., LTD, Guangdong, CN;
Abstract
The present disclosure relates to a scFv amino acid sequence capable of recognizing CD19 antigen and a nucleotide sequence encoding the same, and also relates to a chimeric antigen receptor, a nucleic acid encoding the same and a cell expressing the same, and their uses in the manufacture of a medicament for treating tumors. The chimeric antigen receptor of the present disclosure comprises at least one extracellular domain, an optional transmembrane domain and at least one intracellular costimulatory signaling domain, wherein the extracellular domain comprises a CD19 antigen-recognizing and binding domain. The chimeric antigen receptor of the present disclosure has been humanized, resulting in a longer survival period in vivo, and a corresponding extended complete remission period in patients.