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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11713324 B1

PDFFull Text
Date of Patent:
Aug. 01, 2023

Filed:

Dec. 18, 2020

Gonadotropin-releasing hormone receptor antagonists and methods relating thereto

Applicant:

Neurocrine Biosciences, Inc., San Diego, CA (US);

Inventors:

Graham Beaton, Poway, CA (US);

Mi Chen, San Diego, CA (US);

Timothy Richard Coon, Carlsbad, CA (US);

Todd Ewing, San Diego, CA (US);

Wanlong Jiang, San Diego, CA (US);

Willy Moree, San Diego, CA (US);

Martin Rowbottom, San Diego, CA (US);

Warren Wade, San Diego, CA (US);

Liren Zhao, San Diego, CA (US);

Richard Lowe, Oakland, CA (US);

Nicole Smith, San Diego, CA (US);

Neil Ashweek, San Diego, CA (US);

Yun-Fei Zhu, San Diego, CA (US);

Assignee:

Neurocrine Biosciences, Inc., San Diego, CA (US);

Attorney:

Lauren L. Stevens

Primary Examiner:

Nizal S Chandrakumar

Int. Cl.
CPC ...
C07D 495/04 (2006.01); C07C 233/88 (2006.01); C07C 235/42 (2006.01); C07C 255/57 (2006.01); C07D 213/56 (2006.01); C07D 213/61 (2006.01); C07D 213/64 (2006.01); C07D 213/70 (2006.01); C07D 213/81 (2006.01); C07D 213/84 (2006.01); C07D 213/89 (2006.01); C07D 215/14 (2006.01); C07D 215/54 (2006.01); C07D 401/04 (2006.01); C07D 401/12 (2006.01); C07D 413/12 (2006.01); C07D 417/12 (2006.01); C07D 239/36 (2006.01); C07D 213/58 (2006.01);
U.S. Cl.
CPC ...
C07D 495/04 (2013.01); C07C 233/88 (2013.01); C07C 235/42 (2013.01); C07C 255/57 (2013.01); C07D 213/56 (2013.01); C07D 213/58 (2013.01); C07D 213/61 (2013.01); C07D 213/64 (2013.01); C07D 213/70 (2013.01); C07D 213/81 (2013.01); C07D 213/84 (2013.01); C07D 213/89 (2013.01); C07D 215/14 (2013.01); C07D 215/54 (2013.01); C07D 239/36 (2013.01); C07D 401/04 (2013.01); C07D 401/12 (2013.01); C07D 413/12 (2013.01); C07D 417/12 (2013.01);
Abstract

GnRH receptor antagonists are disclosed which have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure: wherein R, R, R, R, R, R, and A are as defined herein, including stereoisomers, esters, solvates and pharmaceutically acceptable salts thereof. Also disclosed are compositions containing a compound of this invention in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for antagonizing gonadotropin-releasing hormone in a subject in need thereof.

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