The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 01, 2023
Filed:
Mar. 21, 2019
The Regents of the University of California, Oakland, CA (US);
Guillermo Bazan, Santa Barbara, CA (US);
Zichao Zhang, Goleta, CA (US);
Alex Moreland, Santa Barbara, CA (US);
Michael J. Mahan, Santa Barbara, CA (US);
Douglas M. Heithoff, Santa Barbara, CA (US);
Jakkarin Limwongyut, Goleta, CA (US);
Chenyao Nie, Goleta, CA (US);
The Regents Of The University Of California, Oakland, CA (US);
Abstract
Compositions and methods of making and using thereof are provided with a specific antimicrobial activity and efficacy toward Gram-positive and Gram-negative bacteria and low levels of toxicity toward mammalian cells. The compositions include water-soluble molecules characterized by a hydrophobic interior fragment and side groups containing cationic groups. A class of these molecules is provided with variations in the length of the internal conjugated segment and in other molecular features, which impact the efficacy and toxicity. The substituents on the cationic functional group, the structural variations on the solubilizing group, and the length of the conjugated segment are important features affecting the antimicrobial property and the non-toxicity to mammalian cells of the composition.