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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11713308 B1

PDFFull Text
Date of Patent:
Aug. 01, 2023

Filed:

Jul. 06, 2021

3,3-difluoroallylamines or salts thereof and pharmaceutical compositions comprising the same

Applicant:

Yuhan Corporation, Seoul, KR;

Inventors:

Tae Dong Han, Yongin-si, KR;

Hee Jae Tak, Yongin-si, KR;

Eun Kyung Kim, Seongnam-si, KR;

Eui Chul Lee, Yongin-si, KR;

Sol Park, Yongin-si, KR;

Hyok Jun Cho, Hwaseong-si, KR;

Cheol Hee Lim, Suwon-si, KR;

So Young Kim, Suwon-si, KR;

Hyun Ho Choi, Suwon-si, KR;

Da Na Jeong, Seongnam-si, KR;

Na Yeon Yang, Hwaseong-si, KR;

Na Ry Ha, Seoul, KR;

Assignee:

YUHAN CORPORATION, Seoul, KR;

Attorney:

Sheppard Mullin Richter & Hampton LLP

Primary Examiner:

Daniel R Carcanague

Int. Cl.
CPC ...
C07D 403/10 (2006.01); C07D 249/12 (2006.01); C07D 401/04 (2006.01); C07D 401/10 (2006.01); C07D 401/14 (2006.01); C07D 403/04 (2006.01); C07D 403/14 (2006.01); C07D 405/10 (2006.01); C07D 405/14 (2006.01); C07D 409/06 (2006.01); C07D 409/14 (2006.01); C07D 413/14 (2006.01);
U.S. Cl.
CPC ...
C07D 403/10 (2013.01); C07D 249/12 (2013.01); C07D 401/04 (2013.01); C07D 401/10 (2013.01); C07D 401/14 (2013.01); C07D 403/04 (2013.01); C07D 403/14 (2013.01); C07D 405/10 (2013.01); C07D 405/14 (2013.01); C07D 409/06 (2013.01); C07D 409/14 (2013.01); C07D 413/14 (2013.01);
Abstract

The present technology provides 3,3-difluoroallylamines or pharmaceutically acceptable salts thereof, preparation processes thereof, pharmaceutical compositions comprising the same, and uses thereof. The 3,3-difluoroallylamines or their pharmaceutically acceptable salts exhibit potent inhibitory activity on VAP-1 and therefore can be usefully applied, e.g., for the treatment and prophylaxis of nonalcoholic hepatosteatosis (NASH).

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