The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 01, 2023
Filed:
Aug. 05, 2021
National Tsing Hua University, Hsinchu, TW;
Te-Yu Chao, New Taipei, TW;
Yu-Ching Tung, Taoyuan, TW;
Mao-Chih Hsieh, Taipei, TW;
Yu-Ting Tai, Taipei, TW;
Bing-Ying Ho, Taipei, TW;
Wei-Chia Chang, New Taipei, TW;
Sung-Yang Wei, New Taipei, TW;
Chang-Hung Hsieh, New Taipei, TW;
Chung-Cheng Chou, Taoyuan, TW;
Jen-Tsan Chi, Chapel Hill, NC (US);
Long Hsu, Hsinchu, TW;
Hwan-You Chang, Hsinchu, TW;
Huang-Ming Philip Chen, Zhubei, TW;
Cheng-Hsien Liu, Hsinchu, TW;
NATIONAL TSING HUA UNIVERSITY, Hsinchu, TW;
Abstract
A drug screening platform simulating hyperthermic intraperitoneal chemotherapy including a dielectrophoresis system, a microfluidic chip and a heating system is disclosed. The dielectrophoresis system is used to provide a dielectrophoresis force. The microfluidic chip includes a cell culture array and observation module and a drug mixing module. The cell culture array and observation module are used to arrange the cells into a three-dimensional structure through the dielectrophoresis force to construct a three-dimensional tumor microenvironment. The drug mixing module is coupled to the cell culture array and observation module and used to automatically split and mix the inputted drugs and output the drug combinations into the cell culture array and observation module. The heating system is used for real-time temperature sensing and heating control of the drug combinations on the microfluidic chip to simulate high-temperature drug environment when performing hyperthermic intraperitoneal chemotherapy on the three-dimensional tumor microenvironment.