The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 01, 2023
Filed:
Mar. 27, 2019
Applicant:
Minnesota Medical Physics Llc, Eden Prairie, MN (US);
Inventors:
Victor I. Chornenky, Minnetonka, MN (US);
Ali Jaafar, Eden Prairie, MN (US);
Assignee:
Minnesota Medical Physics LLC, Eden Prairie, MN (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61N 2/02 (2006.01); A61N 1/36 (2006.01); A61N 2/00 (2006.01); A61N 1/40 (2006.01); A61K 31/00 (2006.01); A61N 1/32 (2006.01);
U.S. Cl.
CPC ...
A61N 2/02 (2013.01); A61N 1/36002 (2017.08); A61N 1/40 (2013.01); A61N 2/006 (2013.01); A61K 31/00 (2013.01); A61N 1/326 (2013.01); A61N 1/3606 (2013.01); A61N 1/36046 (2013.01);
Abstract
A method and apparatus for treatment of cancer is provided. The method can include systemic delivery of A3 selective adenosine receptor (A3AR) agonists CI-IB-MECA, cordycepin or similar drugs and providing simultaneous pulsed Electric Field (EF) stimulation to the treatment area. EF stimulation can be delivered in three orthogonal directions, which significantly increases expression of A3ARs on the cellular membranes and allows achieving a downstream apoptotic signal that is 4-6 fold stronger than the signal achieved with the agonist drugs alone.