The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 01, 2023
Filed:
Dec. 11, 2020
Washington University, St. Louis, MO (US);
Samuel Achilefu, St. Louis, MO (US);
Rui Tang, St. Louis, MO (US);
Duanwen Shen, St. Louis, MO (US);
Avik Som, St. Louis, MO (US);
Baogang Xu, St. Louis, MO (US);
Gail Sudlow, St. Louis, MO (US);
Christopher Egbulefu, St. Louis, MO (US);
Partha Karmakar, St. Louis, MO (US);
Kexian Liang, St. Louis, MO (US);
WASHINGTON UNIVERSITY, St. Louis, MO (US);
Abstract
Provided herein is a pharmaceutical composition comprising an effective amount of cypate-Cyclo(Cys-Gly-Arg-Asp-Ser-Pro-Cys)-Lys-OH (LS301), cypate-Cyclo(Cys-Gly-Arg-Asp-Ser-Pro-Cys)-Tyr-OH (LS838) or pharmaceutically acceptable salts thereof, wherein each amino acid residue is independently in a D or L configuration; a divalent metal ion; and a pharmaceutically acceptable carrier. Further provided are lyophilized products comprising a dye-conjugate and m methods for identifying compromised and for binding phosphorylated annexin A2 (pANXA2) protein in a biological sample using a composition described herein.