The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 25, 2023
Filed:
Dec. 31, 2018
Howard Hughes Medical Institute, Chevy Chase, MD (US);
Eric R Schreiter, Ashburn, VA (US);
Luke D. Lavis, Leesburg, VA (US);
Claire Deo, Ashburn, VA (US);
Hersh Bhargava, Berkeley, CA (US);
Ahmed Abdelfattah, Ashburn, VA (US);
HOWARD HUGHES MEDICAL INSTITUTE, Chevy Chase, MD (US);
Abstract
A chemigenetic calcium indicator and a method of measuring calcium are provided. The chemigenetic calcium indicator includes a calcium-binding protein domain attached to a ligand binding protein domain. The method of measuring calcium includes administering a chemigenetic calcium indicator to a subject and determining changes in fluorescence, the chemigenetic calcium indicator including a ligand binding protein domain having a calcium-binding protein domain and a dye-ligand conjugate attached thereto.