The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 25, 2023
Filed:
Sep. 28, 2021
Fudan University, Shanghai, CN;
Fener Chen, Shanghai, CN;
Dang Cheng, Shanghai, CN;
Minjie Liu, Shanghai, CN;
Zedu Huang, Shanghai, CN;
Yuan Tao, Shanghai, CN;
Jiaqi Wang, Shanghai, CN;
Fudan University, Shanghai, CN;
Abstract
Disclosed herein relates to organic synthesis, and more particularly to a method for preparing a key intermediate for the synthesis of statins. The key intermediate is 2-[(4R,6S)-6-[(benzo[d]thiazol-2-ylthio)methyl]-2,2-disubstituted-1,3-dioxan-4-yl] acetate of formula (I): where Ris a C-Calkyl group, a C-Ccycloalkyl group, a monosubstituted or polysubstituted aryl group, or monosubstituted or polysubstituted aralkyl group; Ris hydrogen, or monosubstituted or polysubstituted C-Calkyl group, or halogen; and Rand Rare each independently a C-Calkyl group, a C-Ccycloalkyl group, a C-Ccycloalkenyl group, a C-Calkoxy group, a C-Caryl group, or C-Caralkyl group. In the method, a halomethyl compound and a thiol reagent are subjected to nucleophilic substitution in an organic solvent to synthesize a thioether, which then undergoes ketal exchange reaction with a carbonyl compound (V) in the presence of an organic acid to obtain a target product.