The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 25, 2023
Filed:
Sep. 07, 2018
Applicant:
The Regents of the University of California, Oakland, CA (US);
Inventors:
Martin Marsala, Solana Beach, CA (US);
Atsushi Miyanohara, San Diego, CA (US);
Takahiro Tadokoro, San Diego, CA (US);
Assignee:
The Regents of the University of California, Oakland, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 48/00 (2006.01); A61K 35/761 (2015.01); A61K 38/17 (2006.01); A61K 38/51 (2006.01); A61K 9/00 (2006.01); A61P 25/02 (2006.01); A61P 25/04 (2006.01); C12N 15/86 (2006.01); C12N 7/00 (2006.01);
U.S. Cl.
CPC ...
A61K 48/0058 (2013.01); A61K 9/0019 (2013.01); A61K 35/761 (2013.01); A61K 38/1787 (2013.01); A61K 38/51 (2013.01); A61K 48/0025 (2013.01); A61K 48/0075 (2013.01); A61P 25/02 (2018.01); A61P 25/04 (2018.01); C12N 7/00 (2013.01); C12N 15/86 (2013.01); C12N 2750/14143 (2013.01); C12N 2750/14171 (2013.01);
Abstract
The present invention provides a therapy for treating neuropathic pain by subpial administration of small quantities of a composition for spinal segment-specific upregulation of GAD65 (glutamatedecarboxylase) gene and VGAT (vesicular GABA transporter) gene, which is effective for induction of nociceptive effects by potentiating release of vesicular GABA from infected dorsal horn neurons into the synaptic cleft.