The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 18, 2023
Filed:
Jul. 17, 2018
Fraunhofer-gesellschaft Zur Förderung Der Angewandten Forschung E.v., Munich, DE;
Anke Piechotta, Halle, DE;
Kathrin Gnoth, Halle, DE;
Holger Cynis, Halle, DE;
Jens-Ulrich Rahfeld, Seegebiet Mansfelder Land, DE;
Stephan Schilling, Halle, DE;
Hans-Ulrich Demuth, Halle, DE;
Abstract
The present invention can be included in the field of medicine. Specifically, the present invention provides antibodies and antigen-binding fragments thereof which can bind isoAsp7 amyloid β (Aβ) and a pharmaceutical composition comprising the antibodies or antigen-binding fragments thereof. IsoAsp7 Aβ can be found in plaques of Alzheimer's patients and is thus a suitable target for the treatment and/or prevention of Aβ-related diseases such as Alzheimer's disease. Thus, the antibodies, antigen-binding fragments thereof and the pharmaceutical composition comprising either can be used to treat and/or prevent neurodegenerative diseases. Further, the present invention provides hybridoma cell lines, the use of the antibodies or antigen-binding fragments thereof for the diagnosis and/or prognosis of a neurodegenerative disease and a method for detecting isoAsp7 Aβ in an isolated sample.