The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 18, 2023
Filed:
Oct. 18, 2019
Applicant:
University of Florida Research Foundation, Incorporated, Gainesville, FL (US);
Inventors:
Sergei Zolotukhin, Gainesville, FL (US);
Oleksandr Kondratov, Gainesville, FL (US);
Assignee:
University of Florida Research Foundation, Incorporated, Gainesville, FL (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/86 (2006.01); C12N 7/00 (2006.01); C07K 14/075 (2006.01); C12N 5/07 (2010.01);
U.S. Cl.
CPC ...
C12N 15/86 (2013.01); C07K 14/075 (2013.01); C12N 5/0601 (2013.01); C12N 7/00 (2013.01); C12N 2710/14041 (2013.01); C12N 2710/14143 (2013.01); C12N 2710/14144 (2013.01); C12N 2750/14123 (2013.01); C12N 2750/14143 (2013.01); C12N 2750/14151 (2013.01);
Abstract
Provided herein are methods and compositions useful in the production of recombinant AAV (rAAV) in host producer cells, such as insect cells. In some embodiments, methods, uses and compositions are provided that comprise recombinant VP1 genes comprising modified Kozak sequences to express AAV VP1 proteins in amounts that are useful for producing infective rAAV particles. These infective rAAV particles may comprise a gene of interest.