The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 18, 2023

Filed:

Aug. 21, 2020
Applicant:

The Government of the United States of America, As Represented BY the Secretary of the Navy, Arlington, VA (US);

Inventors:

Marc P. Raphael, Springfield, VA (US);

Wonmo Kang, Springfield, VA (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C12M 1/12 (2006.01); C12M 3/00 (2006.01); C12N 5/071 (2010.01); C12M 1/00 (2006.01); C12M 1/42 (2006.01); C12M 1/32 (2006.01);
U.S. Cl.
CPC ...
C12M 25/04 (2013.01); C12M 21/08 (2013.01); C12M 23/12 (2013.01); C12M 23/34 (2013.01); C12M 35/08 (2013.01); C12N 5/0602 (2013.01);
Abstract

A system and method for studying cell injury mechanisms by applying biologically relevant mechanical impact to in vitro cell culture are disclosed. This approach is for maintaining consistent in vitro conditions during experiments, accommodating multiple cell populations, and monitoring each in real-time while achieving amplitude and time scale of input acceleration that mimic blunt injury cases. These multiplexed, environmental control capabilities enable characterizing the relationships between mechanical impact and cell injury in multivariate biological systems.


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