The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 18, 2023
Filed:
Nov. 14, 2019
Applicants:
Medimmune Limited, Cambridge, GB;
Adc Therapeutics S.a., Epalinges, CH;
Inventors:
Patricius Hendrikus Cornelis Van Berkel, Epalinges, CH;
Philip Wilson Howard, Cambridge, GB;
Assignees:
MEDIMMUNE LIMITED, Cambridge, GB;
ADC THERAPEUTICS S.A., Epalinges, CH;
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/00 (2006.01); C07K 16/28 (2006.01); A61K 47/68 (2017.01); A61P 35/02 (2006.01); C07D 487/04 (2006.01);
U.S. Cl.
CPC ...
C07K 16/2803 (2013.01); A61K 47/6803 (2017.08); A61K 47/6867 (2017.08); A61P 35/02 (2018.01); C07D 487/04 (2013.01); C07K 2317/24 (2013.01); C07K 2317/53 (2013.01); Y02P 20/55 (2015.11);
Abstract
Site-specific antibody-drug conjugates are described, in particular conjugates comprising pyrrolobenzodiazepines (PBDs) having a labile protecting group in the form of a linker. The site of conjugation, along with modification of the antibody moiety, allows for improved safety and efficacy of the ADC.