The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 18, 2023
Filed:
Jun. 18, 2021
Biomea Fusion, Llc, Redwood City, CA (US);
Thomas Butler, Redwood City, CA (US);
Jim Palmer, Warrandyte, AU;
Ravi Upasani, San Jose, CA (US);
Matthew Welsch, New Haven, CT (US);
Sridhar Vempati, Edison, NJ (US);
Brendan Kelly, Castlecomer, IE;
Edward Painter, Chappaqua, NY (US);
BIOMEA FUSION, LLC, Redwood City, CA (US);
Abstract
Disclosed herein are heterocyclic compounds according to formula (I) having the structure that inhibit the binding of menin and MLL or MLL fusion proteins. Also described are specific irreversible inhibitors of menin-HLL interaction. Also disclosed are pharmaceutical compositions that include compounds according to formula (I). Methods of using the menin-HLL irreversible inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, leukemia and other diseases or conditions dependent on menin-MLL interaction.