The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 18, 2023
Filed:
Apr. 16, 2021
Applicant:
Regeneren Pharmaceuticals, Inc., Tarrytown, NY (US);
Inventor:
Thomas Nittoli, Pearl River, NY (US);
Assignee:
Regeneron Pharmaceuticals, Inc., Tarrytown, NY (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 47/54 (2017.01); A61K 47/65 (2017.01); A61K 47/55 (2017.01); A61K 47/68 (2017.01); A61P 31/04 (2006.01); A61P 35/00 (2006.01); A61K 31/395 (2006.01); A61K 31/5383 (2006.01); A61K 31/5517 (2006.01); A61K 38/07 (2006.01); A61K 38/17 (2006.01); A61K 49/00 (2006.01); A61K 51/10 (2006.01);
U.S. Cl.
CPC ...
A61K 47/545 (2017.08); A61K 31/395 (2013.01); A61K 31/5383 (2013.01); A61K 31/5517 (2013.01); A61K 38/07 (2013.01); A61K 38/1729 (2013.01); A61K 47/542 (2017.08); A61K 47/55 (2017.08); A61K 47/65 (2017.08); A61K 47/6849 (2017.08); A61K 49/0052 (2013.01); A61K 49/0058 (2013.01); A61K 51/1093 (2013.01); A61P 31/04 (2018.01); A61P 35/00 (2018.01);
Abstract
Described herein are protein-payload conjugates and compositions thereof that are useful, for example, for target-specific delivery of therapeutic and/or imaging agent moieties. In certain embodiments, provided are specific and efficient methods for producing protein-payload constructs (e.g., antibody-drug conjugates) utilizing a combination of transglutaminase and Diels-Alder techniques. Antibody-drug conjugates and compositions which comprise glutaminyl-modified antibodies, Diels-Alder adducts, and reactive payloads and are provided.