The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 18, 2023
Filed:
Feb. 21, 2019
The Scripps Research Institute, La Jolla, CA (US);
Luke L. Lairson, San Diego, CA (US);
Emily Chin, San Diego, CA (US);
Arnab K. Chatterjee, San Diego, CA (US);
Manoj Kumar, San Diego, CA (US);
Ana Maria Gamo Albero, La Jolla, CA (US);
Hank Michael James Petrassi, San Diego, CA (US);
Peter G. Schultz, La Jolla, CA (US);
Chenguang Yu, La Jolla, CA (US);
Junko Tamiya, Carlsbad, CA (US);
William Vernier, Vista, CA (US);
Anil Gupta, San Diego, CA (US);
Ramkumar Modukuri, Houston, TX (US);
The Scripps Research Institute, La Jolla, CA (US);
Abstract
The invention provides compounds having STimulator of INterferon Genes (STING) agonistic bioactivity that can be used in the treatment of tumors in patients afflicted therewith. The compounds are of formula (I): as defined herein. Compounds for practice of a method of the invention can be delivered via oral delivery for systemic exposure, as well as delivered intratumorally. Antitumor therapy using a compound of formula (I) can further comprise administration of an effective dose of an immune-checkpoint targeting drug.