The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 18, 2023
Filed:
Sep. 28, 2018
Relay Therapeutics, Inc., Cambridge, MA (US);
D. E. Shaw Research, Llc, New York, NY (US);
Alexander M. Taylor, Cambridge, MA (US);
W. Patrick Walters, Westborough, MA (US);
Mark Andrew Murcko, Holliston, MA (US);
Fabrizio Giordanetto, New York, NY (US);
Eric Therrien, Bronx, NY (US);
Sathesh Bhat, Jersey City, NJ (US);
Markus Kristofer Dahlgren, Shelton, CT (US);
D. E. Shaw Research, LLC, New York, NY (US);
Relay Therapeutics, Inc., Cambridge, MA (US);
Abstract
Cellular biological activities are tightly controlled by intracellular signaling processes initiated by extracellular signals. Protein tyrosine phosphatases, which remove phosphate groups from tyrosine phosphorylated signaling molecules, play equally important tyrosine roles as protein kinases in signal transduction. SHP-2, a cytoplasmic SH2 domain containing protein tyrosine phosphatase, is involved in the signaling pathways of a variety of growth factors and cytokines. Recent studies have clearly demonstrated that this phosphatase plays an important role in transducing signal relay from the cell surface to the nucleus, and is a critical intracellular regulator in mediating cell proliferation and differentiation.