The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 11, 2023
Filed:
Oct. 30, 2017
Sirnaomics, Inc., Gaithersburg, MD (US);
Jia Zhou, Gaithersburg, MD (US);
Qingfeng LI, Gaithersburg, MD (US);
John Xu, Germantown, MD (US);
Patrick Y. Lu, Potomac, MD (US);
Jia Zhou, Gaithersburg, MD (US);
Qingfeng Li, Shanghai, CN;
Vera Simonenko, Gaithersburg, MD (US);
Sirnaomics, Inc., Germantown, MD (US);
Sirnaomics Medicine Technology (Suzhou) Co, Ltd., Suzhou, CN;
Abstract
The current invention provides a method of activating fibroblast and myofibroblast apoptosis in a tissue of a mammal, comprising administering to the tissue a therapeutically effective amount of a composition comprising an siRNA molecule that binds to an mRNA that codes for TGFB1 protein in a mammalian cell, an siRNA molecule that binds to an mRNA that codes for COX-2 protein in a mammalian cell, and a pharmaceutically acceptable carrier comprising a pharmaceutically acceptable histidine-lysine polymer. The invention also provides additional methods for using this composition.