The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 11, 2023
Filed:
Oct. 01, 2019
Applicant:
The Johns Hopkins University, Baltimore, MD (US);
Inventors:
Jordan J. Green, Nottingham, MD (US);
Martin G. Pomper, Baltimore, MD (US);
Camila Gadens Zamboni, Curitiba, BR;
Hannah Vaughan, Baltimore, MD (US);
Il Minn, Elliott City, MD (US);
Assignee:
The Johns Hopkins University, Baltimore, MD (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C12N 9/12 (2006.01); C12N 15/52 (2006.01); A61K 48/00 (2006.01); C12N 15/85 (2006.01); A61K 35/00 (2006.01); C08G 73/02 (2006.01); A61K 51/04 (2006.01); B82Y 5/00 (2011.01); A61K 45/00 (2006.01); A61K 31/522 (2006.01);
U.S. Cl.
CPC ...
C12N 9/1211 (2013.01); A61K 35/00 (2013.01); A61K 48/0041 (2013.01); C08G 73/02 (2013.01); C12N 15/52 (2013.01); C12N 15/85 (2013.01); A61K 31/522 (2013.01); A61K 45/05 (2013.01); A61K 51/0459 (2013.01); B82Y 5/00 (2013.01); C12N 2820/007 (2013.01); C12N 2830/008 (2013.01); C12N 2830/15 (2013.01); C12N 2840/007 (2013.01); C12N 2840/60 (2013.01); C12Y 207/01021 (2013.01);
Abstract
A DNA plasmid useful for diagnostic and therapeutic gene therapy is disclosed. Improvements to gene therapy methods known in the art are provided to ensure cancer-targeting, high efficacy, and long durability of expression. The DNA plasmid is combined with compositions of polymeric nanoparticles for non-viral gene therapy to treat cancer, including hepatocellular carcinoma and prostate cancer.