The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 11, 2023
Filed:
Oct. 27, 2020
Merck Sharp & Dohme Llc, Rahway, NJ (US);
Indu Bharathan, Somerville, MA (US);
Symon Gathiaka, Waltham, MA (US);
Yongxin Han, Needham, MA (US);
Xiaoshen Ma, Boston, MA (US);
Ryan D. Otte, Natick, MA (US);
David L. Sloman, Newton, MA (US);
Thomas H. Graham, Somerville, MA (US);
Timothy Henderson, Natick, MA (US);
Elisabeth Hennessy, Weston, MA (US);
Anandan Palani, Needham, MA (US);
Merck Sharp & Dohme LLC, Rahway, NJ (US);
Abstract
The disclosure provides compounds of Formula (I) or a pharmaceutically acceptable salt thereof, wherein W, W, Y, Z, M, L, C, C, R, R, R, R, R, R, Rand the subscripts m, n, q, and r are as described herein. The compounds or their pharmaceutically acceptable salts can inhibit the G12C mutant of Kirsten rat sarcoma (KRAS) protein and are expected to have utility as therapeutic agents, for example, for treating cancer. The disclosure also provides pharmaceutical compositions which comprise compounds of Formula (I) or pharmaceutically acceptable salts thereof. The disclosure also relates to methods for use of the compounds or their pharmaceutically acceptable salts in the therapy and prophylaxis of cancer and for preparing pharmaceuticals for this purpose.