The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 11, 2023
Filed:
Mar. 04, 2019
Shanghai Laiyi Center for Biopharmaceutical R&d CO, Shanghai, CN;
Zhejiang Medicine Co., Ltd., Shaoxing, CN;
Chang Shao, Shanghai, CN;
Mei Ge, Shanghai, CN;
Lingao Ruan, Shanghai, CN;
Wei Wei, Shanghai, CN;
Xing Xia, Shanghai, CN;
Min Rao, Shanghai, CN;
Qingqian Meng, Shanghai, CN;
Minyu Luo, Shanghai, CN;
Shanghai LaiYi Center For Biopharmaceutical R&D Co., Ltd., Zhejiang, CN;
Zhejiang Medicine Co., Ltd., Zhejiang, CN;
Abstract
The present invention discloses glycopeptide compounds having activity of resisting drug-resistant bacteria, conforming to glycopeptide compounds represented by general formula (I), The present invention also provides a preparation method for and an application of the glycopeptide compounds. Upon testing, compared with a second-generation glycopeptide drug oritavancin, the glycopeptide antibiotic compounds have higher inhibition activity on drug-resistant bacterial strains, especially MRSA or VRE. Further testing shows that most of the glycopeptide compounds have safety higher than that of oritavancin and can be prepared into drugs for treating or preventing diseases caused by various bacterial infections, such as skin and soft tissue infections, meningitis, sepsis, pneumonia, arthritis, peritonitis, bronchitis, and empyema.