The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 11, 2023
Filed:
Jan. 17, 2018
Applicant:
Memorial Sloan-kettering Cancer Center, New York, NY (US);
Inventors:
Pau Castel, New York, NY (US);
Jose Baselga, New York, NY (US);
Maurizio Scaltriti, New Yok, NY (US);
Assignee:
MEMORIAL SLOAN-KETTERING CANCER CENTER, New York, NY (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/713 (2006.01); A61K 31/506 (2006.01); A61K 31/4439 (2006.01); A61K 31/7105 (2006.01); A61K 31/711 (2006.01); A61K 45/06 (2006.01); A61P 35/00 (2006.01);
U.S. Cl.
CPC ...
A61K 31/713 (2013.01); A61K 31/4439 (2013.01); A61K 31/506 (2013.01); A61K 31/711 (2013.01); A61K 31/7105 (2013.01); A61K 45/06 (2013.01); A61P 35/00 (2018.01);
Abstract
The present invention relates to methods and compositions for inhibiting growth and proliferation of cancer cells resistant to PI3K inhibition using a combination of PDK1, SGK1 and PI3K inhibitors. The present invention is also directed to methods of treating cancer in a subject exhibiting cancer cells resistant to PI3K inhibition, comprising administering inhibitors of PI3K in combination with inhibitors of PDK1 and/or SGK1 to the subject.